Burn Wound Healing Potential of Paragis (Eleusine indica) Leaf Ethanolic Extract Ointment on Sprague Dawley (Rattus norvegicus) Rats

Abstract

This study aimed to investigate the burn wound healing potential of the ethanolic extract and 10% ointment from Paragis (Eleusine indica) leaves. The research utilized the Complete Randomized Design in evaluating the percent wound contraction and epithelialization period (days) of burn wound inflicted on the test animals, Sprague Dawley rats. The 10% ointment prepared from the ethanolic extract of Paragis (E. indica) leaves was found to be non-cytotoxic in the acute dermal toxicity test at the different dosage levels: 2000 mg/kg (limit test), 1000 mg/kg, 500 mg/kg, and 200 mg/kg. The ointment (Treatment 1) produced with ethanolic leaf extract of Paragis, showed the highest percentage (contraction) for it reached 100% within 16 days which was the last day of monitoring, followed by Treatment 2 (Paragis leaf ethanolic extract), because it reached 93.32% wound contraction at the expected day of contraction (16th day). The positive control ranked third with 84.98% wound contraction at day 16, followed by negative control with 66.62% wound contraction.